Project title:
A coupled atrioventricular-aortic setup for in-vitro hemodynamic study of the systemic circulation: Design, fabrication, and physiological relevancy

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Grant information:
AHA

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Relevant publications:
Alavi, R., Aghilinejad, A., Wei, H., Niroumandi, S., Wieman, S. and Pahlevan, N.M., 2022. A coupled atrioventricular-aortic setup for in-vitro hemodynamic study of the systemic circulation: design, fabrication, and physiological relevancy. Plos one, 17(11), p.e0267765.

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Project description:

This dataset is associated with the published study titled "A coupled atrioventricular-aortic setup for in-vitro hemodynamic study of the systemic circulation: Design, fabrication, and 
physiological relevancy." It includes the raw data used in the paper, as well as the raw data underlying the plots presented. The file titled "Pressure waveforms at different anatomical 
sites" contains pressure waveform data from the left ventricle, ascending aorta, and abdominal aorta. The file "Simultaneous aortic pressure-flow measurements at varying cardiac outputs" 
includes both pressure and flow waveforms of the aorta at different cardiac outputs (CO = 2, 3, 4, and 5 L/min), along with the corresponding pressure-flow loops. The heart rate for all 
cases is 75 bpm. The files "Wave intensity profiles at the ascending aorta for varying CO and aortas" and "Aortic input impedance for varying cardiac outputs and aortas" include wave 
intensity profiles and input impedance data measured at the ascending aorta under two conditions: (a) varying cardiac outputs for the same aorta (Aorta-3, CO = 2–5 L/min) and (b) 
different aortas (Aorta-3, 4, 6) at a fixed cardiac output (CO = 5 L/min). The file "Pressure waveforms at various sites for normal and impaired cardiac function" presents waveforms for 
both normal (CO = 5 L/min) and impaired (CO = 2–4 L/min) cardiac function at the left atrium, left ventricle, ascending aorta, and abdominal aorta (Aorta-3, HR = 75 bpm, normal contractility). 
In "Pressure waveforms for varying contractility at different sites," pressure waveforms are shown for high, normal, and low contractility conditions at the same anatomical sites 
(Aorta-4, CO = 5 L/min, HR = 75 bpm). The file "Pressure waveforms for varying heart rates at different sites" contains data from four heart rates (HR = 50, 75, 100, 125 bpm) measured 
at the same anatomical locations (Aorta-3, CO = 5 L/min). The file "Pressure waveforms for normal and high peripheral resistance at various sites" includes data for both normal and high 
afterload conditions, showing immediate dynamic changes without pausing the pump (Aorta-3, HR = 75 bpm). The file "Pressure waveforms for different aortas with varying compliance 
at various sites" presents waveforms from Aorta-1 to Aorta-8, each representing different levels of aortic compliance, measured at the standard anatomical locations (CO = 5 L/min, HR = 75 bpm). 
Lastly, "Pressure waveforms for increased and reduced preload at various sites" provides pressure waveforms under varying preload conditions, again at the same anatomical sites and collected 
in real-time without pausing the pump (Aorta-3, HR = 75 bpm).

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Software: 
Matlab, Excel
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